Glycine microinjected in the rat dorsal vagal nucleus increases arterial pressure.
- 1 June 1988
- journal article
- abstracts
- Published by Wolters Kluwer Health in Hypertension
- Vol. 11 (6_pt_2) , 664-667
- https://doi.org/10.1161/01.hyp.11.6.664
Abstract
Microinjections (25 nl) of glycine into the dorsal motor nucleus of the vagus in 21 rats elicited dose-dependent increases of arterial pressure and heart rate that were not seen with injections adjacent to the dorsal motor nucleus of the vagus. The responses to glycine were neurally mediated and could be blocked either by local pretreatment with strychnine or by combined vagotomy and ganglionic blockade. The data suggest that glycine receptors on, or in the region of, neurons of the dorsal motor nucleus of the vagus may have a role in the regulation of arterial pressure and heart rate.Keywords
This publication has 12 references indexed in Scilit:
- A1 noradrenergic neurons tonically inhibit sympathoexcitatory neurons of C1 area in rat brainstemBrain Research, 1986
- Specificity of spinal projections from hypothalamic and brainstem areas which innervate sympathetic preganglionic neuronsBrain Research, 1985
- Rostral ventrolateral medulla: Selective projections to the thoracic autonomic cell column from the region containing C1 adrenaline neuronsJournal of Comparative Neurology, 1984
- Tonic vasomotor control by the rostral ventrolateral medulla: effect of electrical or chemical stimulation of the area containing C1 adrenaline neurons on arterial pressure, heart rate, and plasma catecholamines and vasopressinJournal of Neuroscience, 1984
- Evidence that GABA and glycine-like inputs inhibit vasodepressor neurons in the caudal ventrolateral medulla of the rabbitNeuroscience Letters, 1983
- Biochemical evidence thatl-glutamate is a neurotransmitter of primary vagal afferent nerve fibersBrain Research, 1981
- The Central Origin of Efferent Pathways in the Carotid Sinus Nerve of the CatScience, 1979
- Involvement of central GABA receptors in the regulation of blood pressure and heart rate of anesthetized catsEuropean Journal of Pharmacology, 1977
- GABA and glycine transport in frog CNS: High affinity uptake and potassium-evoked release in vitroBrain Research, 1976
- Blood pressure effects obtained by drugs applied to the ventral surface of the brain stemThe Journal of Physiology, 1973