The erg gene: a human gene related to the ets oncogene.
- 1 September 1987
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 84 (17) , 6131-6135
- https://doi.org/10.1073/pnas.84.17.6131
Abstract
We have isolated a cDNA clone representing the complete coding sequence of a human gene named erg, related to the ets oncogene. Nucleotide sequence analysis of this cDNA (4.6 kilobases long) revealed that this gene encodes a 363-residue protein whose predicted amino acid sequence showed a homology of .apprxeq. 40% and .apprxeq. 70% to two domains corresponding to the 5'' and 3'' regions of v-ets oncogene, respectively. A 3.2- to 3.6-kilobase and .apprxeq.5-kilobase transcript of the erg gene, which differ in size from those of the previously described Hu-ets 1 and Hu-ets 2 genes, were observed in different cells. These results suggest that the erg gene is a member of the ets oncogene family.Keywords
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