TREATMENT OF MOUSE-TUMORS WITH 7-CON-O-METHYLNOGAROL AND OTHER ANALOGS OF THE ANTHRACYCLINE ANTIBIOTIC, NOGALAMYCIN

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  • 1 January 1979
    • journal article
    • research article
    • Vol. 63  (11-1) , 1971-1978
Abstract
The chemotherapeutic activity of analogs of the anthracycline antibiotic, nogalamycin, was investigated in the P388 and L1210 leukemias and the B16 melanoma in mice. Among the compounds tested, 7-con-O-methylnogarol had superior activity. Depending on the route and schedule of administration, increases in lifespan (ILS) in excess of 100% were observed in all 3 tumor systems. Additional testing of 7-con-O-methylnogarol demonstrated significant activity in the murine colon 26 and colon 38 tumors and the CD8F1 [mouse] mammary tumor. 7-Con-O-methylnogarol was not significantly effective against murine Lewis lung carcinoma, although ILS of 38 and 29% were achieved in 2 experiments. Activity was observed against i.p. inoculated P388 leukemia after i.p., s.c., oral and i.v. drug administration. 7-Con-O-methylnogarol was also highly active (ILS .gtoreq. 120%) after i.p. drug administration to mice were i.v. inoculated P388 leukemia. Significant ILS values resulted from a variety of schedules of administration against i.p. inoculated P388 leukemia and B16 melanoma. Experiments in which the time of single-dose administration was varied prior to the time of i.p. P388 leukemia inoculation showed that residual drug or bioactive drug-related materials remained in mice for 8 h after 50 mg/kg administered i.p. and for 48 h after 200 mg/kg administered s.c.