Metabolic Effects of Phenethyldiguanide, A New Hypoglycemic Compound.

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Abstract
Phenethyldiguanide (PEDG) produces hypoglycemia in guinea pigs when given orally or intravenously. The hypoglycemia is accompanied by depletion of liver glycogen with no increase in muscle glycogen. PEDG causes also a decreased blood urea formation and a decreased non-protein nitrogen excretion in the urine. PEDG produces an early and significant rise in blood lactic acid. It also exerts an effect on isolated rat diaphragm, in which it causes an increased glucose uptake, increased lactic acid production, decreased glycogen formation, and decreased O2 consumption. The action of the compound is best explained as the result of a stimulation of anaerobic glycolysis together with a decreased gluconeogenesis.