Campylobacter Pylori and Non-Ulcer Dyspepsia: 1. The Final Results of a Double-Blind Multicentre Trial for Treatment with Pirenzepine in Italy

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Abstract
In a double-blind multicentre trial to study the effect of pirenzepine in the treatment of non-ulcer dyspepsia, 104 of 128 patients, 52 in each of the study and control groups, completed the 4 weeks of the investigation. There was improvement of the endoscopic and clinical findings but no change of the degree of the mucosal infammation or the extent of colonisation by Campylobacter pylori. The mode of action of pirenzepine in patients with non-ulcer dyspepsia associated with Campylobacter related gastroduodeni-tis remains obscure. Further studies are needed to investigate the possibility of a causal relationship between mucosal colonisation with Campylobacter pylori and gastroduo-denitis specially in cases of non-ulcer dyspepsia.