Involvement of thiols in the induction of inward current induced by silver in frog skeletal muscle membrane
- 1 September 1993
- journal article
- research article
- Published by Springer Nature in Cellular and Molecular Life Sciences
- Vol. 49 (9) , 792-794
- https://doi.org/10.1007/bf01923550
Abstract
Exposure of voltage-clamped frog skeletal muscle fibres to silver caused a maintained inward current which could be carried by Ca2+, Mg2+ or Na+. Inorganic Ca2+ channel blockers and dithiothreitol (SH reducing agent) diminished this current, but a Na+ channel blocker did not. Thus, silver activates the Ca2+ channel by acting on SH groups in a Ca2+ channel protein.Keywords
This publication has 19 references indexed in Scilit:
- Modulation of the Ca2+ channel voltage sensor and excitation-contraction coupling by silverBiophysical Journal, 1992
- Ruthenium red and magnesium ion partially inhibit silver ion-induced release of calcium from sarcoplasmic reticulum of frog skeletal muscles.The Japanese Journal of Physiology, 1989
- Serum Concentrations and Accumulation of Silver in Skin During Three Months Treatment with an Anti-smoking Chewing Gum containing Silver AcetateHuman Toxicology, 1988
- Effects of extracellular calcium and calcium channel blocker on silver-induced contractures in frog skeletal muscle fibers.The Japanese Journal of Physiology, 1987
- Calcium channel selectivity for divalent and monovalent cations. Voltage and concentration dependence of single channel current in ventricular heart cells.The Journal of general physiology, 1986
- Different types of Ca2+ channels in mammalian skeletal muscle cells in culture.Proceedings of the National Academy of Sciences, 1986
- Silver ion-induced tension development and membrane depolarization in frog skeletal muscle fibresPflügers Archiv - European Journal of Physiology, 1985
- Three types of neuronal calcium channel with different calcium agonist sensitivityNature, 1985
- Calcium currents in a fast-twitch skeletal muscle of the rat.The Journal of general physiology, 1983
- Heavy metals induce rapid calcium release from sarcoplasmic reticulum vesicles isolated from skeletal muscle.Proceedings of the National Academy of Sciences, 1983