In-vivo cataractograms using a compact backscatter dynamic light scattering (DLS) probe

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Abstract
A compact fiber optic probe developed by Ansari et al. for fluids experiments in the challenging conditions of a microgravity environment on-board a space shuttle orbiter has been applied to obtain `cataractograms' in transgenic mice to study early onset of cataractogenesis. Cataractograms are topographical contour maps of the lens which are obtained non-invasively by scanning the eye with the probe in three-dimensions (x, y, and z directions). This new method provides a visual means, in false color, for quantitative detection and monitoring of cataracts in the entire lens. The portion of lens mapped is only limited by the degree of pupil dilation. The dilated pupil is about 1 mm for the transgenic mice system reported in this study.

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