INDUCTION OF LIPID-PEROXIDATION IN RATS BY MERCURIC-CHLORIDE

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  • 1 January 1980
    • journal article
    • research article
    • Vol. 28  (1) , 105-112
Abstract
Twenty-four hours after the s.c. injection of 0.015 mmol of HgCl2/kg per day into male rats for 2 days, the rats exhibited biochemical alterations in the kidneys, including diene conjugation absorption in the microsomal lipids, increased malonic dialdehyde content and decreased soluble glutathione (GSH) peroxidase activity. Simultaneous injections of 0.025 mmol of Na2SeO3/kg per day restored the malonic dialdehyde content and the GSH peroxidase activity to normal levels. Incubation of kidney microsomes with low concentrations of HgCl2 resulted in increased formation of lipid peroxides in the presence and the absence of ascorbate, but not in the presence of NADPH.