Emerging roles of PPARS in inflammation and immunity
Top Cited Papers
- 1 October 2002
- journal article
- review article
- Published by Springer Nature in Nature Reviews Immunology
- Vol. 2 (10) , 748-759
- https://doi.org/10.1038/nri912
Abstract
Lipids and lipid metabolism have well-documented regulatory effects on inflammatory processes. Recent work has highlighted the role of the peroxisome proliferator-activated receptors (PPARs)--a subset of the nuclear-hormone-receptor superfamily that are activated by various lipid species--in regulating inflammatory responses. Here, we describe how the PPARs, through their interactions with transcription factors and other cell-signalling systems, have important regulatory roles in innate and adaptive immunity.Keywords
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