2-Trihalogenomethylbenzazoles. Part I. Formation
- 1 January 1967
- journal article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society C: Organic
- Vol. 1, 20-25
- https://doi.org/10.1039/j39670000020
Abstract
Methods of preparation of 2-trihalogenomethyl-benzimidazoles, -benzothiazoles, and -benzoxazoles have been investigated. It has been shown that the reaction of the mono-salts of o-phenylenediamines, o-aminophenols, and o-aminothiophenols with trichloroacetonitrile or trichloroacetimidate esters affords 2-trichloromethyl substituted benzimidazoles, benzoxazoles, and benzothiazoles. This method has been extended to the preparation of 2-trichloromethyl-2-azolines. A general method of preparation of 2,2′-bibenzimidazolyls is also described.Keywords
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