In Vitro Antibacterial Activity of Spectinomycin

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Abstract
The in vitro inhibitory and bactericidal activities of spectinomycin hydrochloride were tested against a variety of bacteria. The antibiotic was inhibitory at 31.2 μg/ml to most strains of Escherichia coli, Klebsiella, Enterobacter , and Staphylococcus epidermidis . Concentrations of antibiotic exhibiting bactericidal activity exceeded the inhibitory concentration by at least fourfold. Regression graphs were plotted for results obtained with 30-, 100-, 200-, and 300-μg spectinomycin discs; tentative interpretative standards are proposed.