Prenatal diagnosis of autosomal recessive osteopetrosis, infantile type, by X‐ray evaluation

Abstract
Prenatal diagnosis for infantile osteopetrosis was attempted during the third pregnancy of a first‐cousin marriage whose family history revealed an affected previous child. At the 25th week of pregnancy, fetal X‐ray evaluation revealed marked sclerosis of osteopetrotic bone and metaphyseal splaying and clubbing of both femurs. The pregnancy was terminated and repeated X‐rays and histopathological examination of fetal bone (femur) confirmed the diagnosis.