THE OESTROGENIC POTENCY IN THE MOUSE OF SEVERAL SUBSTANCES CLOSELY RELATED TO DIETHYLSTILBOESTROL AND MESO-HEXOESTROL

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Abstract
SUMMARY: The effects of oestradiol, diethylstilboestrol, α,α′-dimethylstilbene-4,4′-diol (DMS), α-ethyl-α′-methylstilbene-4,4′-diol (MES), meso-hexoestrol, dl-hexoestrol, meso-butoestrol, dl-butoestroland erythro-α-ethyl-α′-methyl-4,4′-dihydroxybibenzyl (erythro-MEA) on the incorporation of tritiated uridine into uterine RNA were investigated. At 2 hr., valid relative potency estimates with oestradiol were obtained with all substances, and MES, erythro-MEA and meso-butoestrol were almost as potent as diethylstilboestrol and meso-hexoestrol. The time-course of the uridine response to the different substances varied markedly. Injections every 16 hr. of DMS, MES, dl-hexoestrol, meso-butoestrol and erythro-MEA elicited little uterine or vaginal growth, but small doses of these substances given every 4 hr. elicited considerable growth in both organs. It was concluded that the compounds tested were oestrogens and not pro-oestrogens.

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