CULTURE IN COLLAGEN GEL OF HUMAN THYROID CARCINOMAS

  • 1 January 1983
    • journal article
    • research article
    • Vol. 296  (9) , 441-448
Abstract
When seeded on collagen gel surface, human thyroid cells from normal tissue or carcinoma form a monolayer. When the isolated cells are embedded inside the collagen gel, they reorganize into 3-dimensional structures. The cells isolated from normal tissue, adenoma, or well-differentiated follicular carcinoma show the typical arrangement of follicular thyroid cells: the apical poles, characterized by microvilli, are oriented towards the follicular lumen; intercellular junctions are present. In contrast, in the papillary and moderately-differentiated follicular carcinomas, the cells are hardly ever associated, and ultrastructural nuclear anomalies are often observed.

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