SUPPRESSIVE EFFECTS OF A HERBAL FORMULA, TBL‐1, ON TYPE II COLLAGEN‐INDUCED ARTHRITIS IN DBA/1J MICE
- 1 March 1996
- journal article
- research article
- Published by Wiley in Clinical and Experimental Pharmacology and Physiology
- Vol. 23 (3) , 236-240
- https://doi.org/10.1111/j.1440-1681.1996.tb02602.x
Abstract
SUMMARY: 1. The effects of a formula of traditional Chinese medicine, TBL‐1, on collagen‐induced arthritis (CIA) were investigated in DBA/1J mice.2. From 4 weeks after the first immunization with bovine type II collagen (CII), TBL‐1 or indomethacin was administered orally for 13 weeks.3. Clinical scores of CIA were decreased by both TBL‐1 and indomethacin intervention compared with the control CII‐immunized group.4. Radiographic scores of phalangeal destruction were markedly improved by TBL‐1 intervention (PP<0.001).6. These findings suggest that TBL‐1 may play a role in regulating some immune responses in the present arthritis model.Keywords
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