Axonal channelopathies
- 1 July 1996
- journal article
- Published by Wolters Kluwer Health in Neurology
- Vol. 47 (1) , 18-21
- https://doi.org/10.1212/wnl.47.1.18
Abstract
Abnormalities of peripheral nerve Na sup + and K sup + channels result in clinical manifestions unrelated to axonal degeneration or demyelination.Na sup + channel blockade causes weakness and sensory loss associated with slowed conduction and decreased motor and sensory action potential amplitudes. K sup + channel abnormalities result in high frequency repetitive action potentials (e.g., myokymia). Ion channel abnormalities may also play an important role in electrophysiologic changes seen in demyelinating disorders. NEUROLOGY 1996;47: 18-21Keywords
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