Intracellular Traffic of the Mannose 6-Phosphate Receptor and Its Ligands
- 1 January 1987
- book chapter
- Published by Springer Nature
- Vol. 225, 199-212
- https://doi.org/10.1007/978-1-4684-5442-0_17
Abstract
Eukaryotic cells are compartmentalized, increasing the efficiency of the cell by allowing the existence of microenvironments of unique properties and by segregating potentially incompatible biochemical reactions. The targeting of newly synthesized macromolecules to their correct location within the cell and the maintenance of the distinctive macromolecular composition of these compartments is an important feature of cellular organization. The mechanisms by which cells direct the intracellular traffic of macromolecules are the subject of much investigation in cell biology. One well-studied example of intracellular sorting and trafficking is the mannose 6-phosphate-mediated transport of lysosomal enzymes.Keywords
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