The Immediate Effect of Human Renal Transplantation on Basal and Meal-Stimulated Levels of Gastrointestinal Hormones

Publisher Website
Google Scholar
Abstract
Elevated serum levels of gastrin, pancreatic polypeptide, and glucagon were found in 10 uraemic patients, whereas gastric inhibitory polypeptide and somatostatin levels were normal. After renal transplantation there was a significant reduction in serum gastrin (median, 5pmol/l; p=0.05, n=9), pancreatic polypeptide (145 pmol/l; p < 0.01, n=9). GIP (9.5 pmol/l; p=0.02, n=7), and glucagon (92 pg/l; p < 0.02, n=9), whereas no alteration was seen in the somatostatin level. Meal stimulation produced consistent increases in serum levels of all hormones, and the response appeared to be unchanged after renal transplantation.