Precocious Puberty after Hypothalamic and Pituitary Irradiation in Young Children
- 4 October 1984
- journal article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 311 (14) , 920
- https://doi.org/10.1056/nejm198410043111414
Abstract
To the Editor: It is well established that endocrine deficiencies occur after radiotherapy for tumors of the head and neck; growth hormone deficiency is the most frequent consequence.1 , 2 We have shown that gonadotropin deficiency can occur and can prevent, disrupt, or perturb pubertal development.3 The present study reports on a group of children with true precocious puberty possibly related to cranial irradiation. This state of endocrine hyperactivity has had very specific effects on statural growth in these children and hence on therapeutic management.In a retrospective study of 29 children with medulloblastoma (n = 14), head and neck tumors (n . . .Keywords
This publication has 6 references indexed in Scilit:
- Long-Term Treatment of Central Precocious Puberty with a Long-Acting Analogue of Luteinizing Hormone-Releasing HormoneNew England Journal of Medicine, 1983
- Growth and endocrine function after treatment for medulloblastoma.Archives of Disease in Childhood, 1983
- Effect of Hypothalamic and Pituitary Irradiation on Pubertal Development in Children with Cranial TumorsJournal of Clinical Endocrinology & Metabolism, 1982
- Endocrine Sequelae of Antineoplastic Therapy in Childhood Head and Neck Malignancies*Journal of Clinical Endocrinology & Metabolism, 1980
- Hypopituitarism After External IrradiationAnnals of Internal Medicine, 1975
- PITUITARY FUNCTION AFTER TREATMENT OF INTRACRANIAL TUMOURS IN CHILDRENThe Lancet, 1975