Pharmacokinetics and Pharmacodynamics of Thiopental in Patients Undergoing Renal Transplantation

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Abstract
The effects and pharmacokinetics of thiopental were studied in eight patients undergoing renal transplantation. The results were compared with findings in a group of patients with normal renal function. No differences were observed in induction doses or between arterial or venous sleep concentrations. The average V3in the renal failure group was 1441 or 2.5 times the value of the control group (PP3could be explained by the differences in protein binding and when the serum clearance was calculated by using the unbound fraction, this “intrinsic clearance” was significantly lower in the renal failure group (P<0.05). Haemodynamic parameters were determined during the initial 5 min. No significant difference was observed between the thiopental‐induced changes in stroke volume. Cardiac output was unchanged in both patient groups.