Acquired Resistance to Rhipicephalus Appendiculatus (Acari: Ixodidae): Identification of an Antigen Eliciting Resistance in Rabbits1

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Abstract
Immune resistance to infestation by Rhipicephalus appendiculatus, an ixodid tick, was induced in rabbits by repeated tick infestation. Host resistance, which interferes with tick feeding, was expressed as a reduction in tick engorgement weight. Antibodies from resistant hosts were used to isolate several tick salivary gland antigens. These antigens were tested for their ability to produce tick feeding resistance upon injection into susceptible hosts. The results of these experiments suggest that a 90-kilodalton tick salivary gland protein may be useful to induce host resistance to the feeding of ixodid ticks.

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