Investigations of18F—p—fluorophenylalanine for pancreas scanning
- 1 April 1973
- journal article
- Published by Oxford University Press (OUP) in The British Journal of Radiology
- Vol. 46 (544) , 277-288
- https://doi.org/10.1259/0007-1285-46-544-277
Abstract
Studies of the distribution of p-fluorophenylalanine-(14C) and p-fluorophenylalanine-(18F) (18F-pFPA) in rat tissues showed pancreas/liver concentration ratios of up to 7·4:1 at one hour after intravenous injection. Clinical trials in four volunteer patients who received 100 to 300 μCi showed that in only one case was a clear image of the pancreas obtained. Analysis of plasma samples showed that 18F-pFPA was less readily incorporated into plasma proteins than 75Se-selenomethionine. Up to 35 per cent of the injected 18F was recovered in the urine in 12 hours and chromatographic and other analyses suggest that about half the excreted activity was in the form of fluoride. Radiation doses to various organs have been calculated and the doses received by kidney, testes, and whole body were 71, 62, and 46 m rad/mCi respectively.Keywords
This publication has 7 references indexed in Scilit:
- Proceedings of the British Institute of Radiology (Nuclear Medicine Meeting)The British Journal of Radiology, 1971
- Count rate analysis as an adjunct to the75Se-selenomethionine pancreas scanThe British Journal of Radiology, 1969
- Localization in scintiscanning using two isotopesThe International Journal of Applied Radiation and Isotopes, 1968
- A cyclotron method for the production of fluorine-18The International Journal of Applied Radiation and Isotopes, 1966
- In Vivo Formation of Tyrosine from p-Fluorophenylalanine*Biochemistry, 1966
- Studies of plasma volume, red cell volume and total blood volume in young growing ratsThe Journal of Physiology, 1957
- THE TOXICITY OF o- AND p-FLUOROPHENYL-dl-ALANINES FOR THE RATJournal of Biological Chemistry, 1951