Incubation Period and Other Epidemiological Characteristics of 2019 Novel Coronavirus Infections with Right Truncation: A Statistical Analysis of Publicly Available Case Data

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Abstract
The geographic spread of 2019 novel coronavirus (COVID-19) infections from the epicenter of Wuhan, China, has provided an opportunity to study the natural history of the recently emerged virus. Using publicly available event-date data from the ongoing epidemic, the present study investigated the incubation period and other time intervals that govern the epidemiological dynamics of COVID-19 infections. Our results show that the incubation period falls within the range of 2–14 days with 95% confidence and has a mean of around 5 days when approximated using the best-fit lognormal distribution. The mean time from illness onset to hospital admission (for treatment and/or isolation) was estimated at 3–4 days without truncation and at 5–9 days when right truncated. Based on the 95th percentile estimate of the incubation period, we recommend that the length of quarantine should be at least 14 days. The median time delay of 13 days from illness onset to death (17 days with right truncation) should be considered when estimating the COVID-19 case fatality risk.
Funding Information
  • Japan Agency for Medical Research and Development (JP18fk0108050)
  • Japan Society for the Promotion of Science (H.N.: 17H04701, 17H05808, 18H04895 and 19H01074; R.K.: 18J21587)
  • Inamori Foundation (NA)
  • Core Research for Evolutional Science and Technology (JPMJCR1413)
  • Ministry of Education, Culture, Sports, Science and Technology (NA)
  • China Scholarship Council (NA)