The effect of the antiandrogen IIα-hydroxyprogesterone on sebum production and cholesterol concentration of sebum

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Abstract
IIα-Hydroxyprogesterone, a synthetic antiandrogen of low toxicity, was applied topically. In short-term experiments the sebum production of the forehead in normal male subjects was reduced significantly. The cholesterol concentration of sebum decreased to a greater extent. In long-term studies in patients with seborrhoea and male-pattern alopecia, the steroid caused a marked and constant reduction of greasiness of the hair. In this group also, the cholesterol concentration of the sebvim obtained from scalp hair decreased more markedly than total sebum production. Possible effects of IIα-hydroxyprogesterone on androgenic alopecia are discussed.

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