Lethal Hepatic Necrosis After Therapy With Imipramine and Desipramine
- 14 October 1968
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA
- Vol. 206 (3) , 642-645
- https://doi.org/10.1001/jama.1968.03150030098027
Abstract
An apparently allergic reaction manifested by exfoliative dermatitis, mucous membrane desquamation, eosinophilia, severe hepatitis, and death occurred in an 80-year-old woman after therapy with imipramine hydrochloride and desipramine hydrochloride. Autopsy showed massive central and midzonal hepatic necrosis. To the authors' knowledge this is the first report of a lethal hepatic hypersensitivity reaction following administration of these drugs.Keywords
This publication has 0 references indexed in Scilit: