A New Indole Derivative from the Red Alga Chondria atropurpurea. Isolation, Structure Determination, and Anthelmintic Activity

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Abstract
Chondriamide C (3), a new bis(indole) amide, was isolated from the red alga Chondriaatropurpurea, and its structure was established from spectroscopic data and chemical transformations. A new natural product, 3-indoleacrylamide (4), and the previously described chondriamides A and B (1, 2) and 3-indoleacrylic acid (5) were also isolated. The anthelmintic activities of compounds 1, 3, 4, and 6 (the O,N1,N1‘-trimethyl derivative of compound 2) against Nippostrongylusbrasiliensis in vitro were evaluated.