RENAL SIDE-EFFECTS OF TREATMENT WITH CYCLOSPORIN-A IN RHEUMATOID-ARTHRITIS AND AFTER BONE-MARROW TRANSPLANTATION

  • 1 January 1980
    • journal article
    • research article
    • Vol. 110  (52) , 2017-2020
Abstract
Renal function was studied prospectively in 6 patients with rheumatoid arthritis, and non-prospectively in 5 patients after bone marrow transplantation. Both groups were treated with cyclosporin A. Functionally and histologically, the results suggest tubulotoxicity of cyclosporin A, which seems to be dose-related and reversible. Also found in the urine of these patients were yellow, as yet undescribed, crystalline bodies often included in casts.