New Players in the Genetics of Stroke

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Abstract
Stroke is the second leading cause of death and the most common cause of disability in the world. Its incidence is rising with increasing life expectancy. To relieve the heavy burden of stroke, we need to understand the mechanisms that will form the basis of improved prevention and treatment. Ischemic or hemorrhagic stroke is the outcome of a number of different pathophysiological mechanisms, which include cardioembolism, prothrombotic states, and disease of large and small cerebral vessels. Epidemiologic studies involving twins, siblings, or families have found evidence of a genetic influence on stroke. From the clinical point of view, it is . . .
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