The Role of Hemoglobin Denaturation and Band 3 Clustering in Red Blood Cell Aging
- 1 February 1985
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 227 (4686) , 531-533
- https://doi.org/10.1126/science.2578228
Abstract
As hemoglobin begins to denature, it forms hemichromes that cross-link the major erythrocyte membrane-spanning protein, band 3, into clusters. These clusters provide the recognition site for antibodies directed against senescent cells. These antibodies bind to the aged red cell and trigger its removal from circulation.This publication has 19 references indexed in Scilit:
- Hemichrome binding to band 3: nucleation of Heinz bodies on the erythrocyte membraneBiochemistry, 1985
- Binding and lysis of antibody-coated human erythrocytes by activated human monocytesClinical Immunology and Immunopathology, 1984
- Intense, reversible aggregation of intramembrane particles in non-haemolyzed human erythrocytes A freeze-fracture studyBiochimica et Biophysica Acta (BBA) - Biomembranes, 1983
- Phagocytosis of senescent erythrocytes by autologous monocytes: Requirement of membrane-specific autologous IgG for immune elimination of aging red blood cellsCellular Immunology, 1983
- Binding of autologous IgG to human red blood cells before and after ATP-depletion. Selective exposure of binding sites (autoantigens) on spectrin-free vesiclesBiochimica et Biophysica Acta (BBA) - Biomembranes, 1983
- Glycoprotein topology on intact human red blood cells reevaluated by cross-linking following amino group supplementationBiochemistry, 1982
- Aging of the erythrocyte XVII. Binding of autologous immunoglobulin GMechanisms of Ageing and Development, 1982
- Role of physiologic autoantibody in the removal of senescent human red cellsJournal of Supramolecular Structure, 1978
- The band 3 protein of the human red cell membrane: A reviewJournal of Supramolecular Structure, 1978
- OXIDATIVE HEMOLYSIS AND PRECIPITATION OF HEMOGLOBIN. I. HEINZ BODY ANEMIAS AS AN ACCELERATION OF RED CELL AGING *Journal of Clinical Investigation, 1960