PROTEIN INTERACTIONS OF GENTISIC ACID AND CERTAIN OF ITS OXIDATION PRODUCTS 1

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Abstract
Gentisate injected intravenously into mice and rats is very rapidly excreted, disappearing from most organs except skeletal connective tissue, in which it remains for a considerable time. In vitro binding of gentisate to serum albumin was demonstrated to be in molar ratios that characterize other cations of similar molecular size. Oxidation products of gentisate can be separated electro-phoretically into at least 4 distinct components. Some of these appear to be firmly bound to serum proteins and insoluble tissue proteins. Presumably the action of antirheumatic phenols may involve their oxidation in vivo to quinones, which interact with connective tissue.