In vivo DNA repair after N-methyl-N-nitrosourea administration to rats of different ages
- 1 January 1978
- journal article
- research article
- Published by Springer Nature in Zeitschrift für Krebsforschung und Klinische Onkologie
- Vol. 91 (2) , 157-164
- https://doi.org/10.1007/bf00284022
Abstract
DNA repair time-course was studied after injury by N-methyl-N-nitrosourea (MNU) in rat liver cells of animals of different ages and in fetuses using hydroxyurea (HU) as inhibitor of scheduled DNA synthesis. DNA repair was a rapid phenomenon, more so in young adults than in newborns, and was not detectable in fetuses. A correlation seems to exist among organ sensitivity to carcinogen, age of animal and DNA repair.This publication has 21 references indexed in Scilit:
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