Assessing Myocardial Damage in Acute Infarcts

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Abstract
Since investigations in laboratory animals have shown that the size of a myocardial infarction after coronary-artery occlusion can be changed by physiologic and pharmacologic interventions,1 , 2 it has been of great interest to measure extensions and reductions in the size of evolving infarctions in patients. Two technics — mapping of precordial ST-segment elevation3 and disappearance curves of serum creatine phosphokaniase (CPK)4—were developed to measure atraumatically changes in infarct size or myocardial injury in patients. Each of these two methods has its advantages and its inherent shortcomings. Determination of serial serum CPK activity makes it possible to estimate the mass of . . .