The Effect of Ketotifen on Eosinophils as Measured at LTC4 Release and by Chemotaxis
- 1 July 1991
- journal article
- research article
- Published by Oceanside Publications Inc. in Allergy and Asthma Proceedings
- Vol. 12 (4) , 267-271
- https://doi.org/10.2500/108854191778879313
Abstract
We examined the effect of ketotifen on calcium ionophore (A23187)-induced leukotriene C4 (LTC4) release from eosinophils, and platelet activating factor (PAF)-induced eosinophil chemotaxis to estimate the mechanism of the antiasthmatic property of ketotifen. Purified eosinophil suspensions were obtained from eight atopic asthmatic subjects and eight normals. Twenty M of ketotifen significantly inhibited A23187-induced LTC4 release from eosinophils, and 10 M of ketotifen significantly inhibited PAF-induced eosinophil chemotaxis. These findings may demonstrate the antiallergic pharmacological properties of ketotifen.Keywords
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