The role of superoxide anion radical in the reduction of ferritin iron by xanthine oxidase.
Open Access
- 1 February 1974
- journal article
- Published by American Society for Clinical Investigation in Journal of Clinical Investigation
- Vol. 53 (2) , 665-667
- https://doi.org/10.1172/jci107603
Abstract
Superoxide dismutase exerted a pronounced inhibitory effect upon xanthine oxidase-mediated reduction of iron in ferritin, ferric chloride, or ferric ADP. Maximal inhibition was observed when the superoxide dismutase concentration was only about 1% of that found in normal porcine liver. These observations indicate that superoxide anion radical is an intermediate in the reduction of iron by xanthine oxidase in vitro but not in vivo.Keywords
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