Biological Precursors of Biotin and/or Biotin L-Sulfoxide

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Abstract
Pimelic and azelaic acids were found to be precursors of biotin L-sulfoxide in the growth of Aspergillus niger. Shorter chain dicarboxylic acids as well as suberic and sebacic acids are inactive. A number of other miscellaneous compounds including oleic acid, Tween 80, and certain "traumatic acids," with structural or functional relationships to biotin and/or pimelic or azelaic acid only in approximate carbon chain length are inactive. A number of other compounds including cystine and certain purine and pyrimidine derivatives do not augment the dicarboxylic acid effect.
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