Effects of GM1 Ganglioside in Cerebrovascular Diseases: A Double-Blind Trial in 40 Cases

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Abstract
The effects of GM1 ganglioside in cerebrovascular diseases was studied in 40 patients; the treatment (40 mg/day i.m. injection) began after the acute phase and lasted 6 wk; 18 cases took the drug and 16 the placebo. The evaluation of the cases was made by graduating the severity of the clinical signs and some neurophysiological and morphological parameters, i.e., EEG, flash-evoked potentials and computer tomography scans. The drug, in comparison with the placebo treatment, improved the clinical signs and also the neurophysiological parameters, whereas it was ineffective for the morphological damage. The action of GMI ganglioside was of interest in the processes of neurotransmission and neuronal plasticity as described in the experimental animal.