A Radioisotope Method for Studying Cerebral Circulation

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Abstract
Various techniques using radioisotopes for the study of cerebral circulation have received attention recently.1-4 Of interest has been the use of time concentration curves made with radioactive tracer injected intravenously and monitored at the head by externally placed detectors.2,4 These curves appear to be capable of yielding useful information with respect to regional cerebral circulation, and they have been used to compare circulation in different regions of the cerebrum in the same subject with promising results. However, they have not been applicable in the comparison of data obtained from different subjects. In order to compare data it is necessary to define their parameters. When a small amount of solution of radioactive material is injected intravenously it begins to mix with the blood. However, it takes some time for it to mix completely, and it remains relatively concentrated as a bolus during its first passage through the circulation. This