HIV versus Cytotoxic T Lymphocytes — The War Being Lost

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Abstract
Viruses have caused human diseases throughout history.1 They have developed remarkable and unique properties to help them survive. In response to the threat from viruses, the immune system has evolved two major pathways of protection, humoral (antibody) and cellular (T lymphocyte). When infection overwhelms the immune system, the result is acute disease that either ends quickly in death or becomes a chronic persistent infection. In one such battle, the human immunodeficiency virus (HIV) is still winning out over the immune system. To control this plague we must learn the answers to several questions. What are the essential elements in host . . .