Synthesis of 2'-C-Difluoromethyl Substituted Nucleoside Analogs as Ribonucleoside Replacements in Hammerhead Ribozymes

1 May 1995

journal article
Published by Taylor & Francis in Nucleosides, Nucleotides and Nucleic Acids

Vol. 14 (3) , 799-801
https://doi.org/10.1080/15257779508012474

Abstract

2′-Difluoromethyl modified nucleoside analogs 4 and 9 have been prepared and converted into phosphoramidites for the incorporation into hammerhead ribozymes.

Keywords

SUBSTITUTED NUCLEOSIDE
RIBONUCLEOSIDE REPLACEMENTS
DIFLUOROMETHYL SUBSTITUTED
MODIFIED NUCLEOSIDE
CONVERTED
DIFLUOROMETHYL MODIFIED

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