YhbO Protects Cells against Multiple Stresses
- 15 December 2007
- journal article
- Published by American Society for Microbiology in Journal of Bacteriology
- Vol. 189 (24) , 9140-9144
- https://doi.org/10.1128/jb.01208-07
Abstract
YhbO is a member of the DJ-1/ThiJ/Pfp1 superfamily, which includes chaperones, peptidases, and the Parkinson's disease protein DJ-1. A yhbO -disrupted mutant of Escherichia coli is highly sensitive to oxidative, thermal, UV, and pH stresses, and the putative nucleophilic cysteine C104 of YhbO is required for stress resistance. These results suggest that YhbO affects a central process in stress management.Keywords
This publication has 32 references indexed in Scilit:
- Time-Dependent Proteome Alterations under Osmotic Stress during Aerobic and Anaerobic Growth in Escherichia coliJournal of Bacteriology, 2006
- Mutational analysis of DJ-1 in Drosophila implicates functional inactivation by oxidative damage and agingProceedings of the National Academy of Sciences, 2006
- Differential Roles of the Universal Stress Proteins of Escherichia coli in Oxidative Stress Resistance, Adhesion, and MotilityJournal of Bacteriology, 2005
- The Atomic Resolution Crystal Structure of the YajL (ThiJ) Protein from Escherichia coli: A Close Prokaryotic Homologue of the Parkinsonism-associated Protein DJ-1Journal of Molecular Biology, 2005
- DJ-1 Is a Redox-Dependent Molecular Chaperone That Inhibits α-Synuclein Aggregate FormationPLoS Biology, 2004
- Crystal Structures of Human DJ-1 and Escherichia coli Hsp31, Which Share an Evolutionarily Conserved DomainJournal of Biological Chemistry, 2003
- How Well is Enzyme Function Conserved as a Function of Pairwise Sequence Identity?Journal of Molecular Biology, 2003
- Recent advances in the analysis of oxidized proteinsAmino Acids, 2003
- SigM, an Extracytoplasmic Function Sigma Factor ofBacillus subtilis, Is Activated in Response to Cell Wall Antibiotics, Ethanol, Heat, Acid, and Superoxide StressJournal of Bacteriology, 2003
- Degradation of intracellular protein in Salmonella typhimurium peptidase mutantsJournal of Molecular Biology, 1980