A comparison of the pharmacokinetics of 14C-labelled APD and 99mTc-labelled APD in the mouse
- 1 August 1988
- journal article
- research article
- Published by Springer Nature in Calcified Tissue International
- Vol. 43 (2) , 125-127
- https://doi.org/10.1007/bf02555158
Abstract
The disposition of 14C-labelled and 99mTc-labelled ADP has been investigated in the Balb/c mouse following a single ip injection containing ADP (total dose 5mg/kg) labelled partly with carbon-14 and partly with technetium-99m. The plasma clearance of carbon-14 was twice that for technetium-99m and the accumulation of carbon-14 in bone was twice as great as that of technetium-99m. All other tissues assayed (liver, lung, kidney and muscle) contained higher concentrations of technetium-99m than carbon-14. There was a particularly marked accumulation of technetium-99m in the liver. We conclude that pharmacokinetic studies of diphosphonates cannot be conducted reliably with 99mTc-labelled compounds.This publication has 4 references indexed in Scilit:
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