Hepatorenal and Glomerulotubular Imbalance

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Abstract
The "hepatorenal syndrome" presents an easily recognized but infinitely perplexing picture that grows more confusing despite increasing refinement and sophistication of analysis and therapy. The initial stumbling block is the diversity and number of conditions that the term embraces. The liver and kidney both serve as major excretory routes and are therefore simultaneously susceptible to injury by a large variety of toxic agents that can produce a clinically obvious combination of hepatic and renal failure. Each possesses a large vasculature and receives approximately one quarter of the cardiac output each minute in resting man. As a consequence, each is peculiarly . . .