TOXICITY OF ALPHA-DINITROPHENOL
- 30 September 1933
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA
- Vol. 101 (14) , 1053-1055
- https://doi.org/10.1001/jama.1933.02740390011003
Abstract
Prof. C. Heymans of Ghent has recently revived interest in the fever producing properties of nitrated naphthols,1a demonstration of which stimulated Tainter and his colleagues to study alpha-dinitrophenol. Others had shown also that the latter drug causes an increase in cellular oxidation.2Because of its metabolic stimulating qualities, this agent was proposed and used by Cutting, Mehrtens and Tainter3for the clinical treatment of obesity, hypothyroidism and similar depressed metabolic states. They especially warned against its toxicity, stating that "there are limitations to and possible dangers from the use of the drug clinically. It should be used only under strictly controlled conditions." Since hearing this report we have had a case of intolerance to alpha-dinitrophenol which prompted us to inquire into the toxicity of the compound in an effort to determine contraindications to its use and methods for detecting untoward effects. Perkins, in a comprehensive reviewKeywords
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