Regulation of the Immune Response

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Abstract
Spleen cells from nonimmune mice were exposed in vitro to immune complexes containing solubilized sheep erythrocyte antigen and anti-sheep erythrocyte antibody, and then washed thoroughly. These antigen-antibody treated spleen cells displayed a decreased ability to transfer an adoptive immune response against whole sheep erythrocytes into syngeneic lethally irradiated recipients. Treatment with solubilized antigen or antibody alone produced little or no immunosuppression. Antigen-antibody complex suppression of immune competence was demonstrated to be: 1) immunologically specific, 2) not a result of carryover and release of antigen-antibody complexes, 3) rapidly attained (1 hr), 4) dependent on the Fc portion of antibody at low concentrations of antigen-antibody complexes, 5) stable to incubation of the antigen-antibody treated and washed spleen cells in antigen-antibody complex-free environments (in vitro and in vivo), and 6) the result of inactivation of cell-type(s) other than or as well as macrophages. An in vivo counterpart of in vitro antigen-antibody inactivation is described.

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