Synthesis and anthelmintic activity of a series of of pyrazino[2,1-a][2]benzazepine derivatives
- 1 September 1989
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 32 (9) , 2058-2062
- https://doi.org/10.1021/jm00129a007
Abstract
A series of 1,2,3,4,6,7,8,12b-octahydropyrazino[2,1-a][2]benzazepine derivatives was prepared and the cestocidal activity of the compounds evaluated in an in vitro Taenia crassiceps screen. Many of these derivatives proved to be highly active, and 2-(cyclohexylcarbonyl)-4-oxo-1,2,3,4,6,7,8,12b-octahydropyrazino[2,1-a][2]benzazepine, epsiprantel (BAN) (22), was selected for further development. The structure-activity relationships are discussed.This publication has 1 reference indexed in Scilit:
- In vitro development of the strobilar stage of Mesocestoides cortiInternational Journal for Parasitology, 1982