Dephostatin, a novel protein tyrosine phosphatase inhibitor produced by Streptomyces. I. Taxonomy,isolation, and characterization.
Open Access
- 1 January 1993
- journal article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 46 (9) , 1342-1346
- https://doi.org/10.7164/antibiotics.46.1342
Abstract
A novel inhibitor of protein tyrosine phosphatase, dephostatin, was isolated from the culture broth of a strain of Streptomyces. The active principle was extracted from the broth filtrate with ethyl acetate and purified by silica gel chromatography and by HPLC. Dephostatin inhibited protein tyrosine phosphatase prepared from a human neoplastic T-cell line with an IC50 at 7.7 microM. The inhibitory pattern of dephostatin was competitive against the substrate. Dephostatin inhibited the growth of Jurkat cells.Keywords
This publication has 0 references indexed in Scilit: