Factors influencing the healing rate of gastric ulcer in hospitalised subjects.

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Abstract
A multiple linear regression analysis was carried out on 75 inpatients with gastric ulcer. In order to elucidate the effects of various factors.sbd.endoscopic and roentgenological findings, age, sex, medical history, and drugs such as antacids, anticholinergics or both.sbd.on the healing rate, these factors were compared between those with ulcer which healed within 8 wk after treatment and those which did not. In patients > 50 yr of age, alcohol consumption of > 60 g/day until admission, duration of present ulcer pain for over 3 mo., single ulcer, ulcer located in the lesser curvature and uneven elevation around the ulcer, there was significant delaying effect on ulcer healing. Drug ingestion, sex, smoking habits until admission, size, depth and shape of ulcer, coexisting gastritis, and past and family history of ulcer disease had no significant effect on healing after 8 wk. The patients with 2 unfavorable factors (n = 46) had the best healing rate (100%) compared with those with 3 (n = 20) or 4 or more (n = 9) unfavorable factors. The healing rate of the latter 2 groups was 60% and 22%, respectively (P < 0.001). A prognostic score based on these 6 factors represents the severity of gastric ulcer disease with regard to the healing rate in patients prescribed antacids, and/or anticholinergic drugs.