RAPID GAS-CHROMATOGRAPHIC ASSAY OF BUPIVACAINE IN PLASMA
- 12 November 1987
- journal article
- research article
- Published by Wiley in Fundamental & Clinical Pharmacology
- Vol. 1 (6) , 471-478
- https://doi.org/10.1111/j.1472-8206.1987.tb00580.x
Abstract
A method for estimating bupivacaine concentration in human plasma by capillary gas-chromatography using solid injection and nitrogen-specific detection is described. Etidocaine, another anilidetype local anesthetic was used as internal standard and added to the sample before single-step extraction with diethylether. This method demonstrates high sensitivity (6 ng/ml plasma) and combines selectivity, rapidity, and simplicity. Results of this procedure correlate well with those obtained by an HPLC method.Keywords
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