Evaluation of a New Macrocyclic Antibiotic as a Chiral Selector for Use in Capillary Electrophoresis
- 1 March 1997
- journal article
- research article
- Published by Taylor & Francis in Journal of Liquid Chromatography & Related Technologies
- Vol. 20 (6) , 887-898
- https://doi.org/10.1080/10826079708013660
Abstract
A new macrocyclic antibiotic, LY307599, has been evaluated as a chiral selector for the separation of the enantiomers of flurbiprofen using capillary electrophoresis (CE). The effect of varying separation buffer parameters such as buffer strength, pH, LY307599 concentration and methanol concentration were assessed. Using the optimized CE conditions, the separation of flurbiprofen enantiomers can be achieved using LY307599 as a chiral selector.Keywords
This publication has 36 references indexed in Scilit:
- Use of β-cyclodextrin polymer as a chiral selector in capillary electrophoresisJournal of Chromatography A, 1994
- Protein-based capillary affinity gel electrophoresis for the separation of optical isomersAnalytical Chemistry, 1992
- Chiral separations by capillary electrophoresis using cyclodextrin-containing gelsJournal of Chromatography A, 1992
- Enantiomeric resolution by micellar electrokinetic chromatography with chiral surfactantsJournal of Chromatography A, 1990
- Chiral separation of diltiazem, trimetoquinol and related compounds by micellar electrokinetic chromatography with bile saltsJournal of Chromatography A, 1990
- Optimization of binaphthyl enantiomer separations by capillary zone electrophoresis using mobile phases containing bile salts and organic solventJournal of High Resolution Chromatography, 1990
- Application of micellar electrokinetic chromatography to pharmaceutical analysisElectrophoresis, 1990
- Chiral separation of optical isomeric drugs using micellar electrokinetic chromatography and bile saltsJournal of Microcolumn Separations, 1989
- chiral separation by electronkinetic chromatography while bile salt micellesJournal of Chromatography A, 1989
- Use of complexing agents for selective separation in high-performance capillary electrophoresisJournal of Chromatography A, 1988