Chemical Studies on Tuberactinomycin. VII. Synthesis of γ-Hydroxy-β-lysine
- 1 September 1974
- journal article
- Published by Oxford University Press (OUP) in Bulletin of the Chemical Society of Japan
- Vol. 47 (9) , 2292-2296
- https://doi.org/10.1246/bcsj.47.2292
Abstract
γ-Hydroxy-β-lysine is a new basic amino acid isolated from the hydrolyzates of antitubercular peptides, tuberactinomycin A and N. In order to confirm the structure and establish the stereochemistry of the amino acid, two diastereoisomers of γ-hydroxy-Dl-β-lysine were synthesized by Arndt-Eistert synthesis via β-hiydroxyornithine. Synthetic erythro and threo isomers were found to be identical spectroscopically and chromatographically with the corresponding forms obtained from the antibiotics respectively.Keywords
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